A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

Ohm, Joyce E; McGarvey, Kelly M; Yu, Xiaobing; Cheng, Linzhao; Schuebel, Kornel E; Cope, Leslie; Mohammad, Helai P; Chen, Wei; Daniel, Vincent C; Yu, Wayne; Berman, David M; Jenuwein, Thomas; Pruitt, Kevin; Sharkis, Saul J; Watkins, D Neil; Herman, James G; Baylin, Stephen B

Ohm, Joyce E; McGarvey, Kelly M; Yu, Xiaobing; Cheng, Linzhao; Schuebel, Kornel E; Cope, Leslie; Mohammad, Helai P; Chen, Wei; Daniel, Vincent C; Yu, Wayne; Berman, David M; Jenuwein, Thomas; Pruitt, Kevin; Sharkis, Saul J; Watkins, D Neil; Herman, James G; Baylin, Stephen B.

Affiliation

Ohm JE; Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center.

Nat Genet ; 39(2): 237-42, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17211412

Subject(s)

Chromatin/metabolism; DNA Methylation; Genes, Tumor Suppressor; Stem Cells/metabolism; Adult; Cell Proliferation; Embryonic Stem Cells/metabolism; Gene Silencing; Histones/metabolism; Humans; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins/metabolism; Tumor Cells, Cultured

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Stem Cells / Chromatin / Genes, Tumor Suppressor / DNA Methylation Limits: Adult / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2007 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google