Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.

Kobasa, Darwyn; Jones, Steven M; Shinya, Kyoko; Kash, John C; Copps, John; Ebihara, Hideki; Hatta, Yasuko; Kim, Jin Hyun; Halfmann, Peter; Hatta, Masato; Feldmann, Friederike; Alimonti, Judie B; Fernando, Lisa; Li, Yan; Katze, Michael G; Feldmann, Heinz; Kawaoka, Yoshihiro

Kobasa, Darwyn; Jones, Steven M; Shinya, Kyoko; Kash, John C; Copps, John; Ebihara, Hideki; Hatta, Yasuko; Kim, Jin Hyun; Halfmann, Peter; Hatta, Masato; Feldmann, Friederike; Alimonti, Judie B; Fernando, Lisa; Li, Yan; Katze, Michael G; Feldmann, Heinz; Kawaoka, Yoshihiro.

Affiliation

Kobasa D; Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

Nature ; 445(7125): 319-23, 2007 Jan 18.

Article in En | MEDLINE | ID: mdl-17230189

Subject(s)

Immunity, Innate/immunology; Influenza A Virus, H1N1 Subtype/immunology; Influenza A Virus, H1N1 Subtype/pathogenicity; Influenza, Human/immunology; Influenza, Human/virology; Macaca fascicularis/immunology; Macaca fascicularis/virology; Animals; Chemokines/blood; Cytokines/blood; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Influenza A Virus, H1N1 Subtype/genetics; Influenza, Human/blood; Lung/metabolism; Lung/pathology; Lung/virology; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Survival Rate; Time Factors; Virus Replication

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Database: MEDLINE Main subject: Influenza, Human / Influenza A Virus, H1N1 Subtype / Immunity, Innate / Macaca fascicularis Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2007 Type: Article Affiliation country: Canada

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