Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation.

Liu, Jianyong; Martin, Heather; Shamay, Meir; Woodard, Crystal; Tang, Qi-Qun; Hayward, S Diane

Liu, Jianyong; Martin, Heather; Shamay, Meir; Woodard, Crystal; Tang, Qi-Qun; Hayward, S Diane.

Affiliation

Liu J; Johns Hopkins University School of Medicine, Bunting-Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231, USA.

J Virol ; 81(9): 4722-31, 2007 May.

Article in En | MEDLINE | ID: mdl-17314169

Subject(s)

Antigens, Viral/metabolism; Cell Differentiation/physiology; Gene Expression Regulation, Enzymologic/physiology; Glycogen Synthase Kinase 3/metabolism; Herpesvirus 8, Human/metabolism; Nuclear Proteins/metabolism; 3T3-L1 Cells; Animals; CCAAT-Enhancer-Binding Proteins/metabolism; HeLa Cells; Humans; Immunoprecipitation; Mice; Phosphorylation; beta Catenin/metabolism

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Full text: 1 Database: MEDLINE Main subject: Nuclear Proteins / Gene Expression Regulation, Enzymologic / Cell Differentiation / Herpesvirus 8, Human / Glycogen Synthase Kinase 3 / Antigens, Viral Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Virol Year: 2007 Type: Article Affiliation country: United States

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