Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.

Berezowska, Irena; Chung, Nga N; Lemieux, Carole; Wilkes, Brian C; Schiller, Peter W

Berezowska, Irena; Chung, Nga N; Lemieux, Carole; Wilkes, Brian C; Schiller, Peter W.

Affiliation

Berezowska I; Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7.

J Med Chem ; 50(6): 1414-7, 2007 Mar 22.

Article in En | MEDLINE | ID: mdl-17315860

Subject(s)

Enkephalins/chemical synthesis; Peptides, Cyclic/chemical synthesis; Receptors, Opioid, delta/agonists; Receptors, Opioid, mu/agonists; Allyl Compounds/chemical synthesis; Allyl Compounds/chemistry; Allyl Compounds/pharmacology; Animals; Brain/metabolism; Enkephalins/chemistry; Enkephalins/pharmacology; Guinea Pigs; Ileum/drug effects; Ileum/physiology; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Muscle, Smooth/physiology; Peptides, Cyclic/chemistry; Peptides, Cyclic/pharmacology; Radioligand Assay; Rats; Stereoisomerism; Structure-Activity Relationship; Vas Deferens/drug effects; Vas Deferens/physiology

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Full text: 1 Database: MEDLINE Main subject: Peptides, Cyclic / Enkephalins / Receptors, Opioid, delta / Receptors, Opioid, mu Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article

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