Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.

Arikawa, Emi; Ma, Ronald C W; Isshiki, Keiji; Luptak, Ivan; He, Zhiheng; Yasuda, Yutaka; Maeno, Yasuhiro; Patti, Mary Elizabeth; Weir, Gordon C; Harris, Robert A; Zammit, Victor A; Tian, Rong; King, George L

Arikawa, Emi; Ma, Ronald C W; Isshiki, Keiji; Luptak, Ivan; He, Zhiheng; Yasuda, Yutaka; Maeno, Yasuhiro; Patti, Mary Elizabeth; Weir, Gordon C; Harris, Robert A; Zammit, Victor A; Tian, Rong; King, George L.

Affiliation

Arikawa E; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

Diabetes ; 56(5): 1410-20, 2007 May.

Article in En | MEDLINE | ID: mdl-17363743

Subject(s)

Angiotensins/antagonists & inhibitors; Diabetes Mellitus, Experimental/drug therapy; Insulin/therapeutic use; Myocardium/enzymology; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; Captopril/therapeutic use; Cell Membrane/enzymology; Diabetes Mellitus, Experimental/surgery; Drug Implants; Gene Expression Regulation; Heart/drug effects; Islets of Langerhans Transplantation; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferator-Activated Receptors/genetics; Protein Kinase C/metabolism; Protein Kinase C beta; RNA/genetics; Rats; Rats, Inbred Lew; Reference Values; Reverse Transcriptase Polymerase Chain Reaction

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Database: MEDLINE Main subject: Angiotensins / Diabetes Mellitus, Experimental / Insulin / Myocardium Limits: Animals Language: En Journal: Diabetes Year: 2007 Type: Article Affiliation country: United States

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