Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains.

Wiener, John J M; Gomez, Laurent; Venkatesan, Hariharan; Santillán, Alejandro; Allison, Brett D; Schwarz, Kimberly L; Shinde, Shirin; Tang, Liu; Hack, Michael D; Morrow, Brian J; Motley, S Timothy; Goldschmidt, Raul M; Shaw, Karen Joy; Jones, Todd K; Grice, Cheryl A

Wiener, John J M; Gomez, Laurent; Venkatesan, Hariharan; Santillán, Alejandro; Allison, Brett D; Schwarz, Kimberly L; Shinde, Shirin; Tang, Liu; Hack, Michael D; Morrow, Brian J; Motley, S Timothy; Goldschmidt, Raul M; Shaw, Karen Joy; Jones, Todd K; Grice, Cheryl A.

Affiliation

Wiener JJ; Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. Jwiener@prdus.jnj.com

Bioorg Med Chem Lett ; 17(10): 2718-22, 2007 May 15.

Article in En | MEDLINE | ID: mdl-17382544

Subject(s)

Anti-Bacterial Agents/pharmacology; Enzyme Inhibitors/pharmacology; Indazoles/pharmacology; Topoisomerase II Inhibitors; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; Drug Design; Drug Resistance, Multiple/physiology; Enzyme Inhibitors/chemistry; Microbial Sensitivity Tests; Structure-Activity Relationship

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Database: MEDLINE Main subject: Enzyme Inhibitors / Topoisomerase II Inhibitors / Indazoles / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Type: Article Affiliation country: United States

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