Topological and chronological features of the impairment of glucose metabolism induced by 1-methyl-4-phenylpyridinium ion (MPP+) in rat brain slices.
J Neural Transm (Vienna)
; 114(9): 1155-9, 2007 Sep.
Article
in En
| MEDLINE
| ID: mdl-17431733
ABSTRACT
1-Methyl-4-phenylpyridinium (MPP(+)) was added directly to fresh rat brain slices and the dynamic changes in the cerebral glucose metabolic rate (CMRglc) were serially and two-dimensionally measured with [(18)F]2-fluoro-2-deoxy-D-glucose as a tracer. MPP(+) dose-dependently increased CMRglc, reflecting enhanced glycolysis compensating for the decrease in aerobic metabolism. While the CMRglc enhancement induced by MPP(+) (<10 microM) was restricted to the striatum, MPP(+) (>or=10 microM) induced a significant CMRglc enhancement in all brain regions. MPP(+) at high concentration (1 mM) eventually initiated rapid metabolic collapse, with failure to sustain anaerobic glycolysis.
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Database:
MEDLINE
Main subject:
Brain
/
Brain Mapping
/
1-Methyl-4-phenylpyridinium
/
Glucose
/
Herbicides
Limits:
Animals
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2007
Type:
Article
Affiliation country:
Japan