Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P.

Dhir, Vivek; Ivison, Hannah E; Krone, Nils; Shackleton, Cedric H L; Doherty, Aidan J; Stewart, Paul M; Arlt, Wiebke

Dhir, Vivek; Ivison, Hannah E; Krone, Nils; Shackleton, Cedric H L; Doherty, Aidan J; Stewart, Paul M; Arlt, Wiebke.

Affiliation

Dhir V; Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TT, United Kingdom.

Mol Endocrinol ; 21(8): 1958-68, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17505056

Subject(s)

Amino Acid Substitution/genetics; NADPH-Ferrihemoprotein Reductase/physiology; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors; Steroid 21-Hydroxylase/antagonists & inhibitors; Alanine/genetics; Amino Acid Sequence; Animals; Humans; Mice; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase/genetics; Proline/genetics; Rabbits; Rats; Steroid 17-alpha-Hydroxylase/metabolism; Steroid 21-Hydroxylase/metabolism

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Database: MEDLINE Main subject: Steroid 17-alpha-Hydroxylase / Steroid 21-Hydroxylase / NADPH-Ferrihemoprotein Reductase / Amino Acid Substitution Limits: Animals / Humans Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2007 Type: Article Affiliation country: United kingdom

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