The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation.

Merla, Ramanna; Ye, Yumei; Lin, Yu; Manickavasagam, Saraswathy; Huang, Ming-He; Perez-Polo, Regino J; Uretsky, Barry F; Birnbaum, Yochai

Merla, Ramanna; Ye, Yumei; Lin, Yu; Manickavasagam, Saraswathy; Huang, Ming-He; Perez-Polo, Regino J; Uretsky, Barry F; Birnbaum, Yochai.

Affiliation

Merla R; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0553, USA.

Am J Physiol Heart Circ Physiol ; 293(3): H1918-28, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17616749

Subject(s)

Adenosine/metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Mitogen-Activated Protein Kinase 3/metabolism; Nitric Oxide Synthase Type III/metabolism; Proto-Oncogene Proteins c-akt/metabolism; 5'-Nucleotidase/metabolism; Animals; Atorvastatin; Butadienes/pharmacology; Enzyme Inhibitors/pharmacology; Heptanoic Acids/pharmacology; Male; Mice; Mice, Inbred C57BL; Myocardium/metabolism; Nitric Oxide/metabolism; Nitriles/pharmacology; Phosphodiesterase Inhibitors/pharmacology; Phosphorylation/drug effects; Protein Serine-Threonine Kinases/metabolism; Pyrroles/pharmacology; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Purinergic P1/metabolism; Theophylline/pharmacology

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Database: MEDLINE Main subject: Adenosine / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Mitogen-Activated Protein Kinase 3 / Nitric Oxide Synthase Type III / Proto-Oncogene Proteins c-akt Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2007 Type: Article Affiliation country: United States

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