Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway.

Yang, Yun-Bo; Yang, Yi-Xin; Su, Bo; Tang, Yun-Lian; Zhu, Bing-Yang; Hu, Zhuo-Wei; Li, Gui-Yuan; Li, Yuan-Jian; Liao, Duan-Fang

Yang, Yun-Bo; Yang, Yi-Xin; Su, Bo; Tang, Yun-Lian; Zhu, Bing-Yang; Hu, Zhuo-Wei; Li, Gui-Yuan; Li, Yuan-Jian; Liao, Duan-Fang.

Affiliation

Yang YB; Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, China.

Eur J Pharmacol ; 570(1-3): 125-34, 2007 Sep 10.

Article in En | MEDLINE | ID: mdl-17628533

Subject(s)

Angioplasty, Balloon; Antioxidants/pharmacology; Myocytes, Smooth Muscle/drug effects; Probucol/pharmacology; Thoracic Arteries/drug effects; Tunica Intima/drug effects; Animals; Atherosclerosis/metabolism; Atherosclerosis/pathology; Atherosclerosis/therapy; Caveolin 1/metabolism; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Cells, Cultured; Coronary Restenosis/prevention & control; Down-Regulation; Dual Specificity Phosphatase 1/metabolism; Genes, myc/physiology; Humans; Hyperplasia/drug therapy; Hyperplasia/metabolism; MAP Kinase Kinase 1/metabolism; Male; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Muscle, Smooth, Vascular/cytology; Myocytes, Smooth Muscle/cytology; Myocytes, Smooth Muscle/metabolism; Rabbits; Thoracic Arteries/metabolism; Thoracic Arteries/pathology; Transcription Factor AP-1/metabolism; Tunica Intima/pathology

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Database: MEDLINE Main subject: Probucol / Thoracic Arteries / Tunica Intima / Angioplasty, Balloon / Myocytes, Smooth Muscle / Antioxidants Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Pharmacol Year: 2007 Type: Article Affiliation country: China

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