Significant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers.
Biomed Environ Sci
; 20(3): 179-83, 2007 Jun.
Article
in En
| MEDLINE
| ID: mdl-17672206
ABSTRACT
OBJECTIVE:
To investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them.METHODS:
Thirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs were recruited in this study. The levels of plasma BPDE-albumin adducts and urinary 1-OHP were analyzed using high performance liquid chromatography.RESULTS:
The median levels of BPDE-albumin adducts (42.10 fmol/mg albumin) and urinary 1-OHP (5.46 micromol/mol creatinine) were significantly higher in coke oven workers than in controls (14.16 fmol/mg albumin, 2.96 micromol/mol creatinine, respectively; P<0.01). Multiple logistic regression analysis showed that coke oven workers were at higher risk of having BPDE-albumin adduct levels above 25.30 micromol/mg albumin (OR=1.79, P<0.01) and urinary 1-OHP levels above 4.13 micromol/mol creatinine (OR=2.45, P<0.05). There was a positive correlation between the levels of BPDE-albumin adducts and urinary 1-OHP in all subjects (rs=0.349, P<0.01).CONCLUSION:
BPDE-albumin adduct is a useful biomarker for monitoring long-term exposure to PAHs, and plasma BPDE-albumin adducts level is significantly correlated to urinary 1-OHP levels in coke oven workers.
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Database:
MEDLINE
Main subject:
Pyrenes
/
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
/
Serum Albumin
/
Occupational Exposure
/
Coal Mining
/
Coke
/
Mutagens
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Biomed Environ Sci
Journal subject:
SAUDE AMBIENTAL
Year:
2007
Type:
Article
Affiliation country:
China