Antidepressive Agents, Tricyclic/metabolism; Bacterial Proteins/metabolism; Desipramine/metabolism; Neurotransmitter Uptake Inhibitors/metabolism; Plasma Membrane Neurotransmitter Transport Proteins/metabolism; Amino Acid Sequence; Animals; Antidepressive Agents, Tricyclic/chemistry; Bacterial Proteins/chemistry; Binding Sites; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/metabolism; Cell Line; Conserved Sequence; Crystallography, X-Ray; Desipramine/chemistry; Dopamine/chemistry; Dopamine/metabolism; Dopamine Uptake Inhibitors/chemistry; Dopamine Uptake Inhibitors/metabolism; Drosophila Proteins/chemistry; Drosophila Proteins/metabolism; Humans; Leucine/chemistry; Leucine/metabolism; Models, Molecular; Molecular Sequence Data; Neurotransmitter Uptake Inhibitors/chemistry; Norepinephrine/chemistry; Norepinephrine/metabolism; Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors; Norepinephrine Plasma Membrane Transport Proteins/chemistry; Norepinephrine Plasma Membrane Transport Proteins/metabolism; Plasma Membrane Neurotransmitter Transport Proteins/chemistry; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid; Serotonin/chemistry; Serotonin/metabolism; Selective Serotonin Reuptake Inhibitors/chemistry; Selective Serotonin Reuptake Inhibitors/metabolism