Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.

Kerr, Felicity K; Thomas, Adele R; Wijeyewickrema, Lakshmi C; Whisstock, James C; Boyd, Sarah E; Kaiserman, Dion; Matthews, Antony Y; Bird, Phillip I; Thielens, Nicole M; Rossi, Véronique; Pike, Robert N

Kerr, Felicity K; Thomas, Adele R; Wijeyewickrema, Lakshmi C; Whisstock, James C; Boyd, Sarah E; Kaiserman, Dion; Matthews, Antony Y; Bird, Phillip I; Thielens, Nicole M; Rossi, Véronique; Pike, Robert N.

Affiliation

Kerr FK; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

Mol Immunol ; 45(3): 670-7, 2008 Feb.

Article in En | MEDLINE | ID: mdl-17709141

Subject(s)

Complement C1 Inhibitor Protein/chemistry; Complement Pathway, Mannose-Binding Lectin/physiology; Mannose-Binding Protein-Associated Serine Proteases/chemistry; Complement C1/chemistry; Complement C1/genetics; Complement C1/immunology; Complement C1 Inhibitor Protein/genetics; Complement C1 Inhibitor Protein/immunology; Complement C2/chemistry; Complement C2/genetics; Complement C2/immunology; Complement C4/chemistry; Complement C4/genetics; Complement C4/immunology; Humans; Mannose-Binding Lectin/chemistry; Mannose-Binding Lectin/genetics; Mannose-Binding Lectin/immunology; Mannose-Binding Protein-Associated Serine Proteases/genetics; Mannose-Binding Protein-Associated Serine Proteases/immunology; Peptide Library; Substrate Specificity/physiology

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Database: MEDLINE Main subject: Complement Pathway, Mannose-Binding Lectin / Mannose-Binding Protein-Associated Serine Proteases / Complement C1 Inhibitor Protein Type of study: Clinical_trials / Diagnostic_studies Limits: Humans Language: En Journal: Mol Immunol Year: 2008 Type: Article Affiliation country: Australia

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