Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis.

Choi, Jae Young; Joo, Nam Soo; Krouse, Mauri E; Wu, Jin V; Robbins, Robert C; Ianowski, Juan P; Hanrahan, John W; Wine, Jeffrey J

Choi, Jae Young; Joo, Nam Soo; Krouse, Mauri E; Wu, Jin V; Robbins, Robert C; Ianowski, Juan P; Hanrahan, John W; Wine, Jeffrey J.

Affiliation

Choi JY; Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California, USA.

J Clin Invest ; 117(10): 3118-27, 2007 Oct.

Article in En | MEDLINE | ID: mdl-17853942

Subject(s)

Carbachol/pharmacology; Cholinergic Agonists/pharmacology; Cystic Fibrosis/metabolism; Exocrine Glands/metabolism; Mucus/metabolism; Respiratory System/metabolism; Vasoactive Intestinal Peptide/pharmacology; Acetylcholine/metabolism; Animals; Cyclic AMP/metabolism; Cystic Fibrosis/etiology; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Drug Synergism; Exocrine Glands/drug effects; Humans; Swine; Vasoactive Intestinal Peptide/metabolism

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Full text: 1 Database: MEDLINE Main subject: Respiratory System / Carbachol / Vasoactive Intestinal Peptide / Cholinergic Agonists / Cystic Fibrosis / Exocrine Glands / Mucus Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2007 Type: Article Affiliation country: United States

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