Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia.
Haematologica
; 92(10): e98-e100, 2007 Oct.
Article
in En
| MEDLINE
| ID: mdl-18024365
ABSTRACT
We report a fifty-year-old woman presenting with severe aplastic anaemia (SAA) and prolonged high Human Herpesvirus 6 (HHV6) variant A DNAeamia detected by quantitative PCR. Multiple antiviral treatments failed to affect the HHV6 DNAemia and subsequent immunosuppressive treatment reached only partial improvement as judged by bone marrow examinations. The patient remained dependent on thrombocyte transfusions and G-CSF treatment. After one year of steady high HHV6 DNA load in blood, viral chromosomal integration was proved by demonstrating the viral DNA in hair follicles. This condition appeared to be unconnected with, and to have no effect, on the original SAA.
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Database:
MEDLINE
Main subject:
Antiviral Agents
/
DNA, Viral
/
Chromosomes
/
Herpesvirus 6, Human
/
Anemia, Aplastic
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Haematologica
Year:
2007
Type:
Article