EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells.

van der Merwe, Jacques Q; Hollenberg, Morley D; MacNaughton, Wallace K

van der Merwe, Jacques Q; Hollenberg, Morley D; MacNaughton, Wallace K.

Affiliation

van der Merwe JQ; Inflammation Research Network, Department of Physiology, University of Calgary, Calgary, AB, Canada T2N 4N1.

Am J Physiol Gastrointest Liver Physiol ; 294(2): G441-51, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18032480

Subject(s)

Chlorides/metabolism; Epithelial Cells/metabolism; ErbB Receptors/physiology; Intestinal Mucosa/metabolism; Mitogen-Activated Protein Kinases/physiology; Receptor, PAR-2/physiology; Transcriptional Activation/physiology; Biological Transport, Active; Biotransformation; Blotting, Western; Calcium Signaling/physiology; Cell Line; Cyclic AMP-Dependent Protein Kinases/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/physiology; Epithelial Cells/physiology; ErbB Receptors/genetics; Genes, src/physiology; Humans; Intestines/cytology; Intestines/physiology; Phosphorylation; Prostaglandin-Endoperoxide Synthases/metabolism; Protein Kinase C/metabolism; Receptor, PAR-2/biosynthesis; Receptor, PAR-2/genetics

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Database: MEDLINE Main subject: Transcriptional Activation / Chlorides / Mitogen-Activated Protein Kinases / Receptor, PAR-2 / Epithelial Cells / ErbB Receptors / Intestinal Mucosa Limits: Humans Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2008 Type: Article

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