Acute and repeated dose toxicity studies of recombinant saxatilin, a disintegrin from the Korean snake (Gloydius saxatilis).

Sohn, Young-Doug; Hong, Sung-Yu; Cho, Kil-Sang; Choi, Won-Seok; Song, Si-Whan; Bae, Jin-Sook; Kim, Doo-Sik; Chung, Kwang-Hoe

Sohn, Young-Doug; Hong, Sung-Yu; Cho, Kil-Sang; Choi, Won-Seok; Song, Si-Whan; Bae, Jin-Sook; Kim, Doo-Sik; Chung, Kwang-Hoe.

Affiliation

Sohn YD; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul 120-729, Republic of Korea.

Toxicon ; 51(3): 406-17, 2008 Mar 01.

Article in En | MEDLINE | ID: mdl-18155118

Subject(s)

Disintegrins/administration & dosage; Disintegrins/toxicity; Viperidae; Animals; Disintegrins/chemistry; Disintegrins/metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gene Expression Regulation; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Organ Size/drug effects; Organisms, Genetically Modified; Pichia/genetics; Pichia/metabolism; Platelet Aggregation/drug effects; Recombinant Proteins/administration & dosage; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Recombinant Proteins/toxicity; Spleen/drug effects; Spleen/pathology; Urine; Weight Loss/drug effects

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Database: MEDLINE Main subject: Viperidae / Disintegrins Limits: Animals Language: En Journal: Toxicon Year: 2008 Type: Article

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Database: MEDLINE Main subject: Viperidae / Disintegrins Limits: Animals Language: En Journal: Toxicon Year: 2008 Type: Article