In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor.

Zhou, Jianbiao; Khng, Jiaying; Jasinghe, Viraj J; Bi, Chonglei; Neo, Chiew Hoon Serene; Pan, Mengfei; Poon, Lai Fong; Xie, Zhigang; Yu, Hanry; Yeoh, Allen Eng-Juh; Lu, Yi; Glaser, Keith B; Albert, Daniel H; Davidsen, Steven K; Chen, Chien-Shing

Zhou, Jianbiao; Khng, Jiaying; Jasinghe, Viraj J; Bi, Chonglei; Neo, Chiew Hoon Serene; Pan, Mengfei; Poon, Lai Fong; Xie, Zhigang; Yu, Hanry; Yeoh, Allen Eng-Juh; Lu, Yi; Glaser, Keith B; Albert, Daniel H; Davidsen, Steven K; Chen, Chien-Shing.

Affiliation

Zhou J; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Leuk Res ; 32(7): 1091-100, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18160102

Subject(s)

Antineoplastic Agents/therapeutic use; Indazoles/therapeutic use; Leukemia, Myeloid, Acute/drug therapy; Phenylurea Compounds/therapeutic use; Protein Kinase Inhibitors/therapeutic use; fms-Like Tyrosine Kinase 3/metabolism; Bone Marrow Transplantation; HL-60 Cells; Humans; Leukemia, Myeloid, Acute/metabolism; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Transplantation, Heterologous

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Database: MEDLINE Main subject: Phenylurea Compounds / Leukemia, Myeloid, Acute / Protein Kinase Inhibitors / Fms-Like Tyrosine Kinase 3 / Indazoles / Antineoplastic Agents Limits: Humans Language: En Journal: Leuk Res Year: 2008 Type: Article Affiliation country: Singapore

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