Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.

Pérez, Viviana I; Lew, Christie M; Cortez, Lisa A; Webb, Celeste R; Rodriguez, Marisela; Liu, Yuhong; Qi, Wenbo; Li, Yan; Chaudhuri, Asish; Van Remmen, Holly; Richardson, Arlan; Ikeno, Yuji

Pérez, Viviana I; Lew, Christie M; Cortez, Lisa A; Webb, Celeste R; Rodriguez, Marisela; Liu, Yuhong; Qi, Wenbo; Li, Yan; Chaudhuri, Asish; Van Remmen, Holly; Richardson, Arlan; Ikeno, Yuji.

Affiliation

Pérez VI; The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78229, USA.

Free Radic Biol Med ; 44(5): 882-92, 2008 Mar 01.

Article in En | MEDLINE | ID: mdl-18164269

Subject(s)

DNA, Mitochondrial/genetics; Mitochondria, Liver/metabolism; Oxidative Stress/physiology; Reactive Oxygen Species/metabolism; Thioredoxins/physiology; Adenosine Triphosphate/metabolism; Animals; Apoptosis; Cell Respiration; DNA Damage; Electron Transport; Glutathione Peroxidase/metabolism; Hydrogen Peroxide/metabolism; Lipids/analysis; Liver/cytology; Liver/metabolism; Male; Mice; Mice, Knockout; Proteins/metabolism; Subcellular Fractions; Superoxide Dismutase/metabolism; Thioredoxins/genetics

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Full text: 1 Database: MEDLINE Main subject: Thioredoxins / DNA, Mitochondrial / Mitochondria, Liver / Reactive Oxygen Species / Oxidative Stress Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2008 Type: Article Affiliation country: United States

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