IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function.

Salt, Bryn H; Niemela, Julie E; Pandey, Rahul; Hanson, Eric P; Deering, Raquel P; Quinones, Ralph; Jain, Ashish; Orange, Jordan S; Gelfand, Erwin W

Salt, Bryn H; Niemela, Julie E; Pandey, Rahul; Hanson, Eric P; Deering, Raquel P; Quinones, Ralph; Jain, Ashish; Orange, Jordan S; Gelfand, Erwin W.

Affiliation

Salt BH; Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

J Allergy Clin Immunol ; 121(4): 976-82, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18179816

Subject(s)

I-kappa B Kinase/genetics; Mutation; Opportunistic Infections/genetics; Opportunistic Infections/metabolism; Pneumocystis carinii; Pneumonia, Pneumocystis/genetics; Pneumonia, Pneumocystis/metabolism; Toll-Like Receptors/physiology; Humans; Immunoglobulin G/biosynthesis; Immunoglobulin G/blood; Immunoglobulin M/biosynthesis; Immunoglobulin M/blood; Infant; Killer Cells, Natural/immunology; Male; NF-kappa B/biosynthesis; NF-kappa B/metabolism; Opportunistic Infections/immunology; Pneumonia, Pneumocystis/immunology; Signal Transduction/genetics; Signal Transduction/immunology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism

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Full text: 1 Database: MEDLINE Main subject: Pneumonia, Pneumocystis / Opportunistic Infections / Pneumocystis carinii / I-kappa B Kinase / Toll-Like Receptors / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Infant / Male Language: En Journal: J Allergy Clin Immunol Year: 2008 Type: Article Affiliation country: United States

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