Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma.

Cloughesy, Tim F; Yoshimoto, Koji; Nghiemphu, Phioanh; Brown, Kevin; Dang, Julie; Zhu, Shaojun; Hsueh, Teli; Chen, Yinan; Wang, Wei; Youngkin, David; Liau, Linda; Martin, Neil; Becker, Don; Bergsneider, Marvin; Lai, Albert; Green, Richard; Oglesby, Tom; Koleto, Michael; Trent, Jeff; Horvath, Steve; Mischel, Paul S; Mellinghoff, Ingo K; Sawyers, Charles L

Cloughesy, Tim F; Yoshimoto, Koji; Nghiemphu, Phioanh; Brown, Kevin; Dang, Julie; Zhu, Shaojun; Hsueh, Teli; Chen, Yinan; Wang, Wei; Youngkin, David; Liau, Linda; Martin, Neil; Becker, Don; Bergsneider, Marvin; Lai, Albert; Green, Richard; Oglesby, Tom; Koleto, Michael; Trent, Jeff; Horvath, Steve; Mischel, Paul S; Mellinghoff, Ingo K; Sawyers, Charles L.

Affiliation

Cloughesy TF; Department of Neurology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

PLoS Med ; 5(1): e8, 2008 Jan 22.

Article in En | MEDLINE | ID: mdl-18215105

Subject(s)

Antineoplastic Agents/therapeutic use; Brain Neoplasms/drug therapy; Glioblastoma/drug therapy; Neoplasm Proteins/antagonists & inhibitors; PTEN Phosphohydrolase/deficiency; Protein Kinase Inhibitors/therapeutic use; Protein Kinases/physiology; Salvage Therapy; Sirolimus/therapeutic use; Adult; Aged; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacology; Brain Neoplasms/enzymology; Brain Neoplasms/genetics; Brain Neoplasms/surgery; Cell Division/drug effects; Combined Modality Therapy; Disease Progression; Feedback, Physiological; Female; Glioblastoma/enzymology; Glioblastoma/genetics; Glioblastoma/surgery; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local/drug therapy; Neoplasm Recurrence, Local/surgery; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/physiology; Protein Kinase Inhibitors/adverse effects; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Ribosomal Protein S6/metabolism; Signal Transduction/drug effects; Sirolimus/adverse effects; Sirolimus/pharmacology; TOR Serine-Threonine Kinases

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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / Brain Neoplasms / Salvage Therapy / Glioblastoma / Sirolimus / Protein Kinase Inhibitors / PTEN Phosphohydrolase / Neoplasm Proteins / Antineoplastic Agents Type of study: Prognostic_studies / Qualitative_research Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2008 Type: Article Affiliation country: United States

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