Species differences in the response of liver drug-metabolizing enzymes to (S)-4-O-tolylsulfanyl-2-(4-trifluormethyl-phenoxy)-butyric acid (EMD 392949) in vivo and in vitro.

Richert, Lysiane; Tuschl, Gregor; Viollon-Abadie, Catherine; Blanchard, Nadège; Bonet, Alexandre; Heyd, Bruno; Halkic, Nermin; Wimmer, Elmar; Dolgos, Hugues; Mueller, Stefan O

Richert, Lysiane; Tuschl, Gregor; Viollon-Abadie, Catherine; Blanchard, Nadège; Bonet, Alexandre; Heyd, Bruno; Halkic, Nermin; Wimmer, Elmar; Dolgos, Hugues; Mueller, Stefan O.

Affiliation

Richert L; Laboratoire de Biologie Cellulaire, l'Institut Fédératif de Recherches 133, Facultéde Médecine et de Pharmacie, Besançon, France.

Drug Metab Dispos ; 36(4): 702-14, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18216275

Subject(s)

Butyric Acid/administration & dosage; Butyric Acid/pharmacology; Liver/drug effects; Liver/enzymology; Aged; Animals; Butyric Acid/chemistry; Cells, Cultured; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/metabolism; Female; Gene Expression Regulation, Enzymologic/drug effects; Humans; Liver/physiology; Macaca fascicularis; Male; Middle Aged; PPAR alpha/genetics; PPAR alpha/metabolism; Rats; Rats, Wistar; Species Specificity

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Full text: 1 Database: MEDLINE Main subject: Butyric Acid / Liver Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Type: Article Affiliation country: France

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