Crystal structure of D351A and P312A mutant forms of the mammalian sarcoplasmic reticulum Ca(2+) -ATPase reveals key events in phosphorylation and Ca(2+) release.

Marchand, Alexandre; Winther, Anne-Marie Lund; Holm, Peter Joakim; Olesen, Claus; Montigny, Cedric; Arnou, Bertrand; Champeil, Philippe; Clausen, Johannes D; Vilsen, Bente; Andersen, Jens Peter; Nissen, Poul; Jaxel, Christine; Møller, Jesper Vuust; le Maire, Marc

Marchand, Alexandre; Winther, Anne-Marie Lund; Holm, Peter Joakim; Olesen, Claus; Montigny, Cedric; Arnou, Bertrand; Champeil, Philippe; Clausen, Johannes D; Vilsen, Bente; Andersen, Jens Peter; Nissen, Poul; Jaxel, Christine; Møller, Jesper Vuust; le Maire, Marc.

Affiliation

Marchand A; Commissariat à l'Energie Atomique (CEA), Institut de Biologie et de Technologies de Saclay, SBSM, URA CNRS 2096, Laboratoire de Recherche Associé, 17V University of Paris-Sud, Gif sur Yvette, France.

J Biol Chem ; 283(21): 14867-82, 2008 May 23.

Article in En | MEDLINE | ID: mdl-18356161

Subject(s)

Calcium/metabolism; Mutant Proteins/chemistry; Mutant Proteins/metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases/chemistry; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Sarcoplasmic Reticulum/enzymology; Adenosine Triphosphate/metabolism; Animals; Cell Line; Chlorocebus aethiops; Crystallography, X-Ray; Magnesium/metabolism; Models, Molecular; Mutant Proteins/genetics; Mutant Proteins/isolation & purification; Mutation/genetics; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Sarcoplasmic Reticulum/genetics; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics; Sarcoplasmic Reticulum Calcium-Transporting ATPases/isolation & purification; Static Electricity

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Full text: 1 Database: MEDLINE Main subject: Sarcoplasmic Reticulum / Calcium / Mutant Proteins / Sarcoplasmic Reticulum Calcium-Transporting ATPases Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2008 Type: Article Affiliation country: France

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