Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration.

Singh, Karun K; Park, Katya J; Hong, Elizabeth J; Kramer, Bianca M; Greenberg, Michael E; Kaplan, David R; Miller, Freda D

Singh, Karun K; Park, Katya J; Hong, Elizabeth J; Kramer, Bianca M; Greenberg, Michael E; Kaplan, David R; Miller, Freda D.

Affiliation

Singh KK; Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8.

Nat Neurosci ; 11(6): 649-58, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18382462

Subject(s)

Axons/physiology; Brain-Derived Neurotrophic Factor/physiology; Nerve Degeneration/physiopathology; Receptor, Nerve Growth Factor/physiology; Animals; Animals, Newborn; Axons/drug effects; Axotomy/methods; Brain-Derived Neurotrophic Factor/pharmacology; Cells, Cultured; Cholera Toxin/metabolism; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Developmental/drug effects; Gene Expression Regulation, Developmental/physiology; Green Fluorescent Proteins/biosynthesis; Green Fluorescent Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration/drug therapy; Nerve Degeneration/genetics; Nerve Growth Factor/pharmacology; Neurons/cytology; Potassium Chloride/pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor/deficiency; Stilbamidines/metabolism; Superior Cervical Ganglion/cytology; Superior Cervical Ganglion/growth & development; Visual Pathways/growth & development; Visual Pathways/metabolism

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Full text: 1 Database: MEDLINE Main subject: Axons / Brain-Derived Neurotrophic Factor / Receptor, Nerve Growth Factor / Nerve Degeneration Limits: Animals Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2008 Type: Article

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