[Primary chronic autoimmune neutropenia successfully treated with sirolimus]. / Neutropénie auto-immune primaire avec autoanticorps antineutrophiles traitée avec succès par sirolimus.
Rev Med Interne
; 29(11): 940-2, 2008 Nov.
Article
in Fr
| MEDLINE
| ID: mdl-18400338
ABSTRACT
We report a 74-year-old man with severe chronic primary neutropenia (neutrophil count 390 per millimeter cube) uncovered following surgery for perianal abscess collection. Clinical, laboratory and roentgenographic findings revealed no abnormality. Antineutrophil antibodies were positive in two consecutive serum samples. Under cyclosporine, neutrophil count reached 1970 per millimeter cube. However, this therapy was discontinued due to new onset of severe renal failure. After six weeks, neutrophil count was 950 per millimeter cube and sirolimus was started, resulting in renal function improvement and resolution of neutropenia.
Full text:
1
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Sirolimus
/
Neutropenia
Type of study:
Diagnostic_studies
Limits:
Aged
/
Humans
/
Male
Language:
Fr
Journal:
Rev Med Interne
Year:
2008
Type:
Article
Affiliation country:
France