Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects.

Peng, S; Trimble, C; Alvarez, R D; Huh, W K; Lin, Z; Monie, A; Hung, C-F; Wu, T-C

Peng, S; Trimble, C; Alvarez, R D; Huh, W K; Lin, Z; Monie, A; Hung, C-F; Wu, T-C.

Affiliation

Peng S; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

Gene Ther ; 15(16): 1156-66, 2008 Aug.

Article in En | MEDLINE | ID: mdl-18401437

Subject(s)

CD8-Positive T-Lymphocytes/immunology; Cancer Vaccines/analysis; Genetic Therapy/methods; Neoplasms/therapy; Papillomavirus E7 Proteins/immunology; Vaccines, DNA/analysis; Animals; Apoptosis; Biolistics; Calreticulin/genetics; Dendritic Cells/immunology; Humans; Injections, Intradermal; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Neoplasms/immunology; Neoplasms/pathology; Papillomavirus Infections/immunology; Skin/immunology; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / CD8-Positive T-Lymphocytes / Cancer Vaccines / Vaccines, DNA / Papillomavirus E7 Proteins / Neoplasms Limits: Animals / Humans Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2008 Type: Article Affiliation country: United States

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