Dual binding site inhibitors of B-RAF kinase.

Wolin, Ronald L; Bembenek, Scott D; Wei, Jianmei; Crawford, Shelby; Lundeen, Katherine; Brunmark, Anders; Karlsson, Lars; Edwards, James P; Blevitt, Jonathan M

Wolin, Ronald L; Bembenek, Scott D; Wei, Jianmei; Crawford, Shelby; Lundeen, Katherine; Brunmark, Anders; Karlsson, Lars; Edwards, James P; Blevitt, Jonathan M.

Affiliation

Wolin RL; Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. RWOLIN@PRDUS.JNJ.COM

Bioorg Med Chem Lett ; 18(9): 2825-9, 2008 May 01.

Article in En | MEDLINE | ID: mdl-18434146

Subject(s)

Computer-Aided Design; Hydrocarbons, Aromatic/pharmacology; Imidazoles/pharmacology; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Adenosine Triphosphate/metabolism; Allosteric Site; Crystallography, X-Ray; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Hydrocarbons, Aromatic/chemical synthesis; Imidazoles/chemical synthesis; Inhibitory Concentration 50; Phosphorylation/drug effects; Protein Kinase Inhibitors/chemical synthesis; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Computer-Aided Design / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Hydrocarbons, Aromatic / Imidazoles Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States

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