Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension.

Yang, Jun; Davies, Rachel J; Southwood, Mark; Long, Lu; Yang, Xudong; Sobolewski, Anastasia; Upton, Paul D; Trembath, Richard C; Morrell, Nicholas W

Yang, Jun; Davies, Rachel J; Southwood, Mark; Long, Lu; Yang, Xudong; Sobolewski, Anastasia; Upton, Paul D; Trembath, Richard C; Morrell, Nicholas W.

Affiliation

Yang J; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge CB2 2QQ, United Kingdom.

Circ Res ; 102(10): 1212-21, 2008 May 23.

Article in En | MEDLINE | ID: mdl-18436795

Subject(s)

Bone Morphogenetic Protein Receptors, Type II/genetics; Hypertension, Pulmonary/genetics; Inhibitor of Differentiation Protein 1/genetics; Inhibitor of Differentiation Protein 2/genetics; Muscle, Smooth, Vascular/physiology; Pulmonary Artery/cytology; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II/metabolism; Bone Morphogenetic Proteins/metabolism; Bone Morphogenetic Proteins/pharmacology; Cells, Cultured; Family Health; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Humans; Inhibitor of Differentiation Protein 1/metabolism; Inhibitor of Differentiation Protein 2/metabolism; MAP Kinase Signaling System/physiology; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Muscle, Smooth, Vascular/cytology; Mutation; Phosphorylation; Smad1 Protein/metabolism; Smad5 Protein/metabolism

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Full text: 1 Database: MEDLINE Main subject: Pulmonary Artery / Bone Morphogenetic Protein Receptors, Type II / Inhibitor of Differentiation Protein 1 / Inhibitor of Differentiation Protein 2 / Hypertension, Pulmonary / Muscle, Smooth, Vascular Limits: Humans Language: En Journal: Circ Res Year: 2008 Type: Article Affiliation country: United kingdom

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