Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Zhu, Yuping; Olson, Steven H; Graham, Donald; Patel, Gool; Hermanowski-Vosatka, Anne; Mundt, Steven; Shah, Kashmira; Springer, Marty; Thieringer, Rolf; Wright, Samuel; Xiao, Jianying; Zokian, Hratch; Dragovic, Jasminka; Balkovec, James M

Zhu, Yuping; Olson, Steven H; Graham, Donald; Patel, Gool; Hermanowski-Vosatka, Anne; Mundt, Steven; Shah, Kashmira; Springer, Marty; Thieringer, Rolf; Wright, Samuel; Xiao, Jianying; Zokian, Hratch; Dragovic, Jasminka; Balkovec, James M.

Affiliation

Zhu Y; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. yuping_zhu@merck.com

Bioorg Med Chem Lett ; 18(11): 3412-6, 2008 Jun 01.

Article in En | MEDLINE | ID: mdl-18440812

Subject(s)

11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors; Enzyme Inhibitors/chemical synthesis; Triazoles/chemical synthesis; Triazoles/pharmacology; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone/analysis; Cortisone/blood; Disease Models, Animal; Enzyme Inhibitors/pharmacokinetics; Enzyme Inhibitors/pharmacology; Humans; Hydrocortisone/analysis; Hydrocortisone/blood; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles/pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Triazoles / 11-beta-Hydroxysteroid Dehydrogenase Type 1 / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United States

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