DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.

Zhou, Xiaoling; Zimonjic, Drazen B; Park, Sang-Won; Yang, Xu-Yu; Durkin, Marian E; Popescu, Nicholas C

DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.

Zhou, Xiaoling; Zimonjic, Drazen B; Park, Sang-Won; Yang, Xu-Yu; Durkin, Marian E; Popescu, Nicholas C.

Affiliation

Zhou X; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Int J Oncol ; 32(6): 1285-91, 2008 Jun.

Article in En | MEDLINE | ID: mdl-18497990

Subject(s)

Actins/metabolism; Carcinoma, Hepatocellular/prevention & control; Liver Neoplasms/prevention & control; Lung Neoplasms/prevention & control; Skin Neoplasms/pathology; Tumor Suppressor Proteins/physiology; rhoA GTP-Binding Protein/metabolism; Animals; Apoptosis; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/secondary; Cell Proliferation; Collagen/metabolism; Cytoskeleton/metabolism; Down-Regulation; Drug Combinations; GTPase-Activating Proteins; Humans; Laminin/metabolism; Liver Neoplasms/genetics; Liver Neoplasms/secondary; Lung Neoplasms/genetics; Lung Neoplasms/secondary; Matrix Metalloproteinase 9/metabolism; Matrix Metalloproteinase Inhibitors; Mice; Mice, Nude; Neoplasm Invasiveness; Osteopontin/antagonists & inhibitors; Osteopontin/metabolism; Proteoglycans/metabolism; Tumor Cells, Cultured; rhoA GTP-Binding Protein/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: Skin Neoplasms / Actins / Carcinoma, Hepatocellular / RhoA GTP-Binding Protein / Tumor Suppressor Proteins / Liver Neoplasms / Lung Neoplasms Limits: Animals / Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2008 Type: Article Affiliation country: United States

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