Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem
; 51(14): 4239-52, 2008 Jul 24.
Article
in En
| MEDLINE
| ID: mdl-18578472
Full text:
1
Database:
MEDLINE
Main subject:
Piperidines
/
Pyrroles
/
Kinesins
/
Taxoids
/
Enzyme Inhibitors
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2008
Type:
Article
Affiliation country:
United States