Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures.

Nolte, Marc W; Löscher, Wolfgang; Herden, Christiane; Freed, William J; Gernert, Manuela

Nolte, Marc W; Löscher, Wolfgang; Herden, Christiane; Freed, William J; Gernert, Manuela.

Affiliation

Nolte MW; Department of Pharmacology, Neuroscience Discovery Research, Abbott GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany.

Neurobiol Dis ; 31(3): 342-54, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18632280

Subject(s)

Brain Tissue Transplantation/methods; Epilepsy/metabolism; Epilepsy/surgery; Substantia Nigra/metabolism; Substantia Nigra/surgery; gamma-Aminobutyric Acid/biosynthesis; Animals; Brain Tissue Transplantation/adverse effects; Cell Line, Transformed; Disease Models, Animal; Epilepsy/physiopathology; Female; Genetic Therapy/methods; Glutamate Decarboxylase/genetics; Graft Rejection/immunology; Graft Rejection/metabolism; Graft Rejection/prevention & control; Humans; Kindling, Neurologic/metabolism; Microglia/immunology; Neural Inhibition/physiology; Neurons/cytology; Neurons/metabolism; Neurons/transplantation; Rats; Rats, Wistar; Risk Assessment; Stem Cell Transplantation/adverse effects; Stem Cell Transplantation/methods; Substantia Nigra/physiopathology; Transfection/methods; Treatment Outcome; Up-Regulation/genetics

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Full text: 1 Database: MEDLINE Main subject: Substantia Nigra / Brain Tissue Transplantation / Epilepsy / Gamma-Aminobutyric Acid Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2008 Type: Article Affiliation country: Germany

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