Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence.

Kim, Hyung-Do; Guo, Tiffany W; Wu, Angela P; Wells, Alan; Gertler, Frank B; Lauffenburger, Douglas A

Kim, Hyung-Do; Guo, Tiffany W; Wu, Angela P; Wells, Alan; Gertler, Frank B; Lauffenburger, Douglas A.

Affiliation

Kim HD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Mol Biol Cell ; 19(10): 4249-59, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18632979

Subject(s)

Brain Neoplasms/pathology; Epidermal Growth Factor/metabolism; Glioblastoma/pathology; Brain Neoplasms/metabolism; Cell Line, Tumor; Cell Membrane/metabolism; Cell Movement; Collagen/chemistry; Collagen/metabolism; Glioblastoma/metabolism; Green Fluorescent Proteins/metabolism; Humans; Ligands; Matrix Metalloproteinase 14/metabolism; Models, Biological; Peptide Hydrolases/metabolism; Time Factors; rac1 GTP-Binding Protein/metabolism

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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Epidermal Growth Factor Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Biol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2008 Type: Article Affiliation country: United States

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