Leader of the pack: gene mapping in dogs and other model organisms.
Nat Rev Genet
; 9(9): 713-25, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18714291
ABSTRACT
The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. We share many diseases with our canine companions, including cancer, diabetes and epilepsy, making the dog an ideal model organism for comparative disease genetics. Using newly developed resources, whole-genome association in dog breeds is proving to be exceptionally powerful. Here, we review the different trait-mapping strategies, some key biological findings emerging from recent studies and the implications for human health. We also discuss the development of similar resources for other vertebrate organisms.
Full text:
1
Database:
MEDLINE
Main subject:
Dogs
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Genet
Journal subject:
GENETICA
Year:
2008
Type:
Article
Affiliation country:
United States