Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Raben, Nina; Hill, Victoria; Shea, Lauren; Takikita, Shoichi; Baum, Rebecca; Mizushima, Noboru; Ralston, Evelyn; Plotz, Paul

Raben, Nina; Hill, Victoria; Shea, Lauren; Takikita, Shoichi; Baum, Rebecca; Mizushima, Noboru; Ralston, Evelyn; Plotz, Paul.

Affiliation

Raben N; Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov

Hum Mol Genet ; 17(24): 3897-908, 2008 Dec 15.

Article in En | MEDLINE | ID: mdl-18782848

Subject(s)

Autophagy; Glycogen Storage Disease Type II/pathology; Muscle, Skeletal/pathology; Muscular Diseases/etiology; Muscular Diseases/pathology; Proteins/adverse effects; Proteins/metabolism; Ubiquitination; Animals; Autophagy/genetics; Female; Glycogen Storage Disease Type II/enzymology; Glycogen Storage Disease Type II/genetics; Male; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal/enzymology; Muscle, Skeletal/metabolism; Muscular Diseases/metabolism; Proteins/genetics; Ubiquitination/genetics; alpha-Glucosidases/deficiency; alpha-Glucosidases/genetics

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Proteins / Glycogen Storage Disease Type II / Muscle, Skeletal / Ubiquitination / Muscular Diseases Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2008 Type: Article Affiliation country: United States

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