Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.

Tong, Carl W; Stelzer, Julian E; Greaser, Marion L; Powers, Patricia A; Moss, Richard L

Tong, Carl W; Stelzer, Julian E; Greaser, Marion L; Powers, Patricia A; Moss, Richard L.

Affiliation

Tong CW; Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

Circ Res ; 103(9): 974-82, 2008 Oct 24.

Article in En | MEDLINE | ID: mdl-18802026

Subject(s)

Cardiomegaly/enzymology; Carrier Proteins/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Myocardial Contraction; Myocardium/enzymology; Adrenergic beta-Agonists/pharmacology; Animals; Cardiomegaly/diagnostic imaging; Cardiomegaly/physiopathology; Carrier Proteins/genetics; Dobutamine/pharmacology; Echocardiography, Doppler; Humans; Kinetics; Mechanotransduction, Cellular; Mice; Mice, Transgenic; Muscle Strength; Mutation; Myocardial Contraction/drug effects; Myocardium/pathology; Myofibrils/enzymology; Phosphorylation; Sarcomeres/enzymology; Troponin I/metabolism

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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / Cardiomegaly / Cyclic AMP-Dependent Protein Kinases / Myocardial Contraction / Myocardium Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Circ Res Year: 2008 Type: Article Affiliation country: United States

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