Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).

Seiwert, Scott D; Andrews, Steven W; Jiang, Yutong; Serebryany, Vladimir; Tan, Hua; Kossen, Karl; Rajagopalan, P T Ravi; Misialek, Shawn; Stevens, Sarah K; Stoycheva, Antitsa; Hong, Jin; Lim, Sharlene R; Qin, Xiaoli; Rieger, Robert; Condroski, Kevin R; Zhang, Hailong; Do, Mary Geck; Lemieux, Christine; Hingorani, Gary P; Hartley, Dylan P; Josey, John A; Pan, Lin; Beigelman, Leonid; Blatt, Lawrence M

Seiwert, Scott D; Andrews, Steven W; Jiang, Yutong; Serebryany, Vladimir; Tan, Hua; Kossen, Karl; Rajagopalan, P T Ravi; Misialek, Shawn; Stevens, Sarah K; Stoycheva, Antitsa; Hong, Jin; Lim, Sharlene R; Qin, Xiaoli; Rieger, Robert; Condroski, Kevin R; Zhang, Hailong; Do, Mary Geck; Lemieux, Christine; Hingorani, Gary P; Hartley, Dylan P; Josey, John A; Pan, Lin; Beigelman, Leonid; Blatt, Lawrence M.

Affiliation

Seiwert SD; InterMune, Inc., 3280 Bayshore Blvd., Brisbane, CA 94005, USA. sseiwert@intermune.com

Antimicrob Agents Chemother ; 52(12): 4432-41, 2008 Dec.

Article in En | MEDLINE | ID: mdl-18824605

Subject(s)

Antiviral Agents; Carrier Proteins/antagonists & inhibitors; Hepacivirus/drug effects; Hepacivirus/enzymology; Protease Inhibitors; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Proteins/antagonists & inhibitors; Animals; Antiviral Agents/chemistry; Antiviral Agents/metabolism; Antiviral Agents/pharmacology; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Synergism; Hepacivirus/genetics; Hepacivirus/physiology; Humans; Interferon alpha-2; Interferon-alpha/pharmacology; Intracellular Signaling Peptides and Proteins; Liver/metabolism; Macaca fascicularis; Polyethylene Glycols/pharmacology; Protease Inhibitors/chemistry; Protease Inhibitors/metabolism; Protease Inhibitors/pharmacology; Rats; Recombinant Proteins; Virus Replication/drug effects

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Viral Proteins / Carrier Proteins / Viral Nonstructural Proteins / Hepacivirus Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2008 Type: Article Affiliation country: United States

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