Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

Milicic, Anita; Harrison, Lea-Anne; Goodlad, Robert A; Hardy, Robert G; Nicholson, Anna M; Presz, Michal; Sieber, Oliver; Santander, Sonia; Pringle, James H; Mandir, Nikki; East, Philip; Obszynska, Jolanta; Sanders, Scott; Piazuelo, Elena; Shaw, Jacqui; Harrison, Rebecca; Tomlinson, Ian P; McDonald, Stuart A C; Wright, Nicholas A; Jankowski, Janusz A Z

Milicic, Anita; Harrison, Lea-Anne; Goodlad, Robert A; Hardy, Robert G; Nicholson, Anna M; Presz, Michal; Sieber, Oliver; Santander, Sonia; Pringle, James H; Mandir, Nikki; East, Philip; Obszynska, Jolanta; Sanders, Scott; Piazuelo, Elena; Shaw, Jacqui; Harrison, Rebecca; Tomlinson, Ian P; McDonald, Stuart A C; Wright, Nicholas A; Jankowski, Janusz A Z.

Affiliation

Milicic A; Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom.

Cancer Res ; 68(19): 7760-8, 2008 Oct 01.

Article in En | MEDLINE | ID: mdl-18829530

Subject(s)

Adenoma/genetics; Cadherins/genetics; Cell Proliferation; Colorectal Neoplasms/genetics; DNA Methylation; Intestinal Mucosa/pathology; Promoter Regions, Genetic; Adenoma/metabolism; Adenoma/pathology; Animals; Cadherins/metabolism; Cell Division/genetics; Cell Division/physiology; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Gastrointestinal Neoplasms/genetics; Gastrointestinal Neoplasms/metabolism; Gene Expression Regulation, Neoplastic/physiology; Humans; Intestinal Mucosa/metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Precancerous Conditions/genetics; Precancerous Conditions/metabolism; Precancerous Conditions/pathology; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Adenoma / Cadherins / Promoter Regions, Genetic / DNA Methylation / Cell Proliferation / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2008 Type: Article Affiliation country: United kingdom

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