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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
Sankaranarayanan, Sethu; Holahan, Marie A; Colussi, Dennis; Crouthamel, Ming-Chih; Devanarayan, Viswanath; Ellis, Joan; Espeseth, Amy; Gates, Adam T; Graham, Samuel L; Gregro, Allison R; Hazuda, Daria; Hochman, Jerome H; Holloway, Katharine; Jin, Lixia; Kahana, Jason; Lai, Ming-tain; Lineberger, Janet; McGaughey, Georgia; Moore, Keith P; Nantermet, Philippe; Pietrak, Beth; Price, Eric A; Rajapakse, Hemaka; Stauffer, Shaun; Steinbeiser, Melissa A; Seabrook, Guy; Selnick, Harold G; Shi, Xiao-Ping; Stanton, Matthew G; Swestock, John; Tugusheva, Katherine; Tyler, Keala X; Vacca, Joseph P; Wong, Jacky; Wu, Guoxin; Xu, Min; Cook, Jacquelynn J; Simon, Adam J.
Affiliation
  • Sankaranarayanan S; Department of Alzheimer's Research, WP 26A-2000, Merck Research Labs, 770 Sumneytown Pike, West Point, PA 19486, USA.
J Pharmacol Exp Ther ; 328(1): 131-40, 2009 Jan.
Article in En | MEDLINE | ID: mdl-18854490
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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Amyloid Precursor Protein Secretases Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2009 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Amyloid Precursor Protein Secretases Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2009 Type: Article Affiliation country: United States