The effect of chitosan molecular weight on the characteristics of spray-dried methotrexate-loaded chitosan microspheres for nasal administration.

Sun, Yu; Cui, Fude; Shi, Kai; Wang, Jiamiao; Niu, Mengmeng; Ma, Ruijing

Sun, Yu; Cui, Fude; Shi, Kai; Wang, Jiamiao; Niu, Mengmeng; Ma, Ruijing.

Affiliation

Sun Y; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.

Drug Dev Ind Pharm ; 35(3): 379-86, 2009 Mar.

Article in En | MEDLINE | ID: mdl-18951272

Subject(s)

Antimetabolites, Antineoplastic/administration & dosage; Chitosan/chemistry; Drug Carriers/chemistry; Methotrexate/administration & dosage; Adhesiveness; Administration, Intranasal; Animals; Antimetabolites, Antineoplastic/chemistry; Antimetabolites, Antineoplastic/toxicity; Anura; Calorimetry, Differential Scanning; Cilia/drug effects; Delayed-Action Preparations; Methotrexate/chemistry; Methotrexate/toxicity; Microspheres; Molecular Weight; Particle Size; Toxicity Tests

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Full text: 1 Database: MEDLINE Main subject: Drug Carriers / Methotrexate / Chitosan / Antimetabolites, Antineoplastic Limits: Animals Language: En Journal: Drug Dev Ind Pharm Year: 2009 Type: Article Affiliation country: China

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