Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.

Bunnage, Mark E; Mathias, John P; Wood, Anthony; Miller, Duncan; Street, Stephen D A

Bunnage, Mark E; Mathias, John P; Wood, Anthony; Miller, Duncan; Street, Stephen D A.

Affiliation

Bunnage ME; Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. mark.bunnage@pfizer.com

Bioorg Med Chem Lett ; 18(23): 6033-6, 2008 Dec 01.

Article in En | MEDLINE | ID: mdl-18951784

Subject(s)

Erectile Dysfunction/drug therapy; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors/chemical synthesis; Phosphodiesterase Inhibitors/pharmacokinetics; Piperazines/chemical synthesis; Piperazines/pharmacokinetics; Sulfones/chemical synthesis; Sulfones/pharmacokinetics; 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors; Combinatorial Chemistry Techniques; Cyclic Nucleotide Phosphodiesterases, Type 6/antagonists & inhibitors; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; Phosphodiesterase Inhibitors/chemistry; Phosphodiesterase Inhibitors/pharmacology; Piperazines/chemistry; Piperazines/pharmacology; Purines/chemical synthesis; Purines/chemistry; Purines/pharmacokinetics; Purines/pharmacology; Sildenafil Citrate; Structure-Activity Relationship; Sulfones/chemistry; Sulfones/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Piperazines / Sulfones / Phosphodiesterase 5 Inhibitors / Erectile Dysfunction Limits: Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: United kingdom

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