Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway.

Lee, S-T; Wu, T-T; Yu, P-Y; Chen, R-M

Lee, S-T; Wu, T-T; Yu, P-Y; Chen, R-M.

Affiliation

Lee ST; Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, Republic of China.

Br J Anaesth ; 102(1): 80-9, 2009 Jan.

Article in En | MEDLINE | ID: mdl-19001360

Subject(s)

Anesthetics, Dissociative/pharmacology; Apoptosis/drug effects; Hepatocytes/drug effects; Ketamine/pharmacology; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Caspases/metabolism; DNA Fragmentation; Dose-Response Relationship, Drug; Hepatocytes/metabolism; Humans; Membrane Potential, Mitochondrial; Mitochondria/metabolism; Peptide Hydrolases/metabolism; Signal Transduction; Tumor Cells, Cultured; bcl-2-Associated X Protein/metabolism

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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Hepatocytes / Ketamine / Anesthetics, Dissociative Limits: Humans Language: En Journal: Br J Anaesth Year: 2009 Type: Article Affiliation country: China

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