Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.

Mi, Jin-xia; Wang, Guang-feng; Wang, Heng-bang; Sun, Xiao-qing; Ni, Xin-yan; Zhang, Xiong-wen; Tang, Jia-ming; Yang, Da-jun

Mi, Jin-xia; Wang, Guang-feng; Wang, Heng-bang; Sun, Xiao-qing; Ni, Xin-yan; Zhang, Xiong-wen; Tang, Jia-ming; Yang, Da-jun.

Affiliation

Mi JX; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Acta Pharmacol Sin ; 29(12): 1467-77, 2008 Dec.

Article in En | MEDLINE | ID: mdl-19026166

Subject(s)

Antibiotics, Antineoplastic; Apoptosis/drug effects; Carcinoma, Hepatocellular/drug therapy; Doxorubicin; Gossypol/analogs & derivatives; Liver Neoplasms/drug therapy; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Animals; Antibiotics, Antineoplastic/pharmacology; Antibiotics, Antineoplastic/therapeutic use; Carcinoma, Hepatocellular/pathology; Carcinoma, Hepatocellular/physiopathology; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin/pharmacology; Doxorubicin/therapeutic use; Drug Therapy, Combination; Gossypol/pharmacology; Gossypol/therapeutic use; Humans; In Situ Nick-End Labeling; Liver Neoplasms/pathology; Liver Neoplasms/physiopathology; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Transplantation, Heterologous

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Full text: 1 Database: MEDLINE Main subject: Gossypol / Doxorubicin / Apoptosis / Carcinoma, Hepatocellular / Proto-Oncogene Proteins c-bcl-2 / Liver Neoplasms / Antibiotics, Antineoplastic Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2008 Type: Article Affiliation country: China

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