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The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P.
Choi, Sun J; Marazita, Mary L; Hart, P Suzanne; Sulima, Pawel P; Field, L Leigh; McHenry, Toby Goldstein; Govil, Manika; Cooper, Margaret E; Letra, Ariadne; Menezes, Renato; Narayanan, Somnya; Mansilla, Maria Adela; Granjeiro, José M; Vieira, Alexandre R; Lidral, Andrew C; Murray, Jeffrey C; Hart, Thomas C.
Affiliation
  • Choi SJ; Human Craniofacial Genetic Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892-1423, USA.
Eur J Hum Genet ; 17(6): 774-84, 2009 Jun.
Article in En | MEDLINE | ID: mdl-19092777
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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Platelet-Derived Growth Factor / Cleft Lip / Cleft Palate / Lymphokines / Promoter Regions, Genetic / Polymorphism, Single Nucleotide Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur J Hum Genet Journal subject: GENETICA MEDICA Year: 2009 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Platelet-Derived Growth Factor / Cleft Lip / Cleft Palate / Lymphokines / Promoter Regions, Genetic / Polymorphism, Single Nucleotide Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur J Hum Genet Journal subject: GENETICA MEDICA Year: 2009 Type: Article Affiliation country: United States