p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles.

Curtis, A M; Wilkinson, P F; Gui, M; Gales, T L; Hu, E; Edelberg, J M

Curtis, A M; Wilkinson, P F; Gui, M; Gales, T L; Hu, E; Edelberg, J M.

Affiliation

Curtis AM; GlaxoSmithKline, King of Prussia, PA, USA. Annie.curtis@sfi.ie

J Thromb Haemost ; 7(4): 701-9, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19192109

Subject(s)

Cell-Derived Microparticles/metabolism; Endothelial Cells/ultrastructure; Inflammation Mediators/metabolism; Protein Kinase Inhibitors/pharmacology; p38 Mitogen-Activated Protein Kinases/physiology; Cell-Derived Microparticles/drug effects; Cells, Cultured; Endothelial Cells/immunology; Endothelium, Vascular; Humans; Signal Transduction; Tumor Necrosis Factor-alpha/pharmacology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: Inflammation Mediators / Endothelial Cells / P38 Mitogen-Activated Protein Kinases / Protein Kinase Inhibitors / Cell-Derived Microparticles Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Thromb Haemost Journal subject: HEMATOLOGIA Year: 2009 Type: Article Affiliation country: United States

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