DAMPs ramp up drug toxicity.
J Clin Invest
; 119(2): 246-9, 2009 Feb.
Article
in En
| MEDLINE
| ID: mdl-19244605
ABSTRACT
The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and colleagues report that DNA released from dying hepatocytes is a key stimulus of innate immune activation in the acetaminophen-treated mouse liver (see the related article beginning on page 305). They present evidence indicating that hepatocyte DNA promotes immune activation by acting as a danger-associated molecular pattern (DAMP) that stimulates cytokine production in neighboring sinusoidal endothelial cells via Tlr9 and the Nalp3 inflammasome.
Full text:
1
Database:
MEDLINE
Main subject:
Analgesics, Non-Narcotic
/
Toll-Like Receptors
/
Inflammation
/
Liver
/
Acetaminophen
Limits:
Animals
Language:
En
Journal:
J Clin Invest
Year:
2009
Type:
Article
Affiliation country:
United States