Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.

Arechiga, Adrian F; Habib, Tania; He, Yantao; Zhang, Xian; Zhang, Zhong-Yin; Funk, Andrew; Buckner, Jane H

Arechiga, Adrian F; Habib, Tania; He, Yantao; Zhang, Xian; Zhang, Zhong-Yin; Funk, Andrew; Buckner, Jane H.

Affiliation

Arechiga AF; Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

J Immunol ; 182(6): 3343-7, 2009 Mar 15.

Article in En | MEDLINE | ID: mdl-19265110

Subject(s)

Alleles; Autoimmune Diseases/genetics; B-Lymphocyte Subsets/immunology; Genetic Variation/immunology; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics; Signal Transduction/immunology; Autoimmune Diseases/metabolism; Autoimmune Diseases/pathology; B-Lymphocyte Subsets/metabolism; B-Lymphocyte Subsets/pathology; Humans; Immunologic Memory/genetics; Lymphocyte Activation/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 22/biosynthesis; Protein Tyrosine Phosphatase, Non-Receptor Type 22/physiology; Receptors, Antigen, B-Cell/genetics; Receptors, Antigen, B-Cell/physiology; Signal Transduction/genetics

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Full text: 1 Database: MEDLINE Main subject: Autoimmune Diseases / Genetic Variation / Signal Transduction / B-Lymphocyte Subsets / Alleles / Protein Tyrosine Phosphatase, Non-Receptor Type 22 Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Immunol Year: 2009 Type: Article Affiliation country: United States

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