GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol.

Ting-A-Kee, Ryan; Dockstader, Colleen; Heinmiller, Andrew; Grieder, Taryn; van der Kooy, Derek

Ting-A-Kee, Ryan; Dockstader, Colleen; Heinmiller, Andrew; Grieder, Taryn; van der Kooy, Derek.

Affiliation

Ting-A-Kee R; Institute of Medical Science, University of Toronto, ON, Canada. r_kee@yahoo.com

Eur J Neurosci ; 29(6): 1235-44, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19302158

Subject(s)

Dopamine/metabolism; Ethanol/adverse effects; Motivation; Pedunculopontine Tegmental Nucleus/physiology; Receptors, GABA-A/physiology; Substance Withdrawal Syndrome/psychology; Analysis of Variance; Animals; Behavior, Animal/drug effects; Bicuculline/pharmacology; Cocaine/pharmacology; Conditioning, Operant/drug effects; Conditioning, Operant/physiology; Dopamine Uptake Inhibitors/pharmacology; Dose-Response Relationship, Drug; Female; Functional Laterality; GABA Antagonists/pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine/pharmacology; Narcotics/pharmacology; Pedunculopontine Tegmental Nucleus/drug effects; Pedunculopontine Tegmental Nucleus/injuries; Receptors, Dopamine D2/deficiency; Reinforcement, Psychology; Substance Withdrawal Syndrome/genetics; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Substance Withdrawal Syndrome / Dopamine / Receptors, GABA-A / Pedunculopontine Tegmental Nucleus / Ethanol / Motivation Limits: Animals Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2009 Type: Article Affiliation country: Canada

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