Xist gene regulation at the onset of X inactivation.
Curr Opin Genet Dev
; 19(2): 122-6, 2009 Apr.
Article
in En
| MEDLINE
| ID: mdl-19345091
ABSTRACT
The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is not sufficient to repress Xist in pluripotent cells and there is emerging evidence that transcription factors associated with pluripotency are involved in Tsix-independent repression. This review focuses on recent advances in this area and discusses the implications for our understanding of Xist gene regulation at the onset of X inactivation.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Developmental
/
RNA, Untranslated
/
X Chromosome Inactivation
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2009
Type:
Article
Affiliation country:
United kingdom