The Pic protease of enteroaggregative Escherichia coli promotes intestinal colonization and growth in the presence of mucin.

Harrington, Susan M; Sheikh, Jalaluddin; Henderson, Ian R; Ruiz-Perez, Fernando; Cohen, Paul S; Nataro, James P

Harrington, Susan M; Sheikh, Jalaluddin; Henderson, Ian R; Ruiz-Perez, Fernando; Cohen, Paul S; Nataro, James P.

Affiliation

Harrington SM; Center for Vaccine Development, University of Maryland, Baltimore, MD 21201, USA.

Infect Immun ; 77(6): 2465-73, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19349428

Subject(s)

Escherichia coli Proteins/physiology; Escherichia coli/enzymology; Escherichia coli/growth & development; Mucins/metabolism; Polysaccharide-Lyases/metabolism; Serine Endopeptidases/physiology; Virulence Factors/physiology; Amino Acid Substitution/genetics; Animals; Catalytic Domain; Cecum/microbiology; Child; Colony Count, Microbial; Escherichia coli/isolation & purification; Escherichia coli Proteins/genetics; Feces/microbiology; Female; Gene Deletion; Humans; Intestinal Mucosa/microbiology; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Polysaccharide-Lyases/genetics; Serine Endopeptidases/genetics; Shigella flexneri/genetics; Virulence; Virulence Factors/genetics

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Full text: 1 Database: MEDLINE Main subject: Polysaccharide-Lyases / Serine Endopeptidases / Escherichia coli Proteins / Virulence Factors / Escherichia coli / Mucins Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Child / Female / Humans Language: En Journal: Infect Immun Year: 2009 Type: Article Affiliation country: United States

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